The Nobel Prize in Chemistry for 2003: The Breakthough of Cell Membranes Channel
The Nobel Prize in Chemistry for 2003 was awarded to the American scientist,
Peter Agre and Roderick MacKinnon because of their decisive contribution to
channels in cell membranes. Bengt Nordén, Chairman of the Nobel Committee for Chemistry, said on the press conference,
Agre won the prize for his discovery of the water channel in cell membranes and
Roderick MacKinnon, for structural and mechanistic studies of ion channels.
Their discoveries have clarified how salts (ions) and water are transported out
of and into the cells of the body, for example, the kidneys recover water from
primary urine and how the electrical signals in our nerve cells are generated
and propagated. This is very important for our study of many diseases of, such
as the kidneys, heart, muscles and nervous system. Usually, the Nobel Prize
should be awarded to the senior scientist whose achievement would be tested for
several decades, but Agre was only 54 years old and Mackinnon, 47. Their
achievement was very new. Mackinnon’s discovery just happened 5 years ago and Agre’s work just finished in 1988. The Sweden Press said, it’s very rare in the history of Nobel Prize in Science. This year’s Nobel Prizes in Chemistry, Physiology and Medicine illustrate the
interdisciplinary Research trend of contemporary science.
One hundred of years ago, people suspected the body's cells must contain
specific channels for transporting water. However, it was not until 1988 that
Peter Agre succeeded in isolating a membrane protein. Then he realized it must
be the long-sought-after water channel. The selection Committee said, it is a
decisive discovery which opened the door to a whole series of biochemical,
physiological and genetic studies of water channels in bacteria, plants and
The other type of membrane channel is the ion channel important for the function
of then nerve system or muscle. It also can generate the electrical signal to
pass the message in nerve system. Roderick MacKinnon surprised the whole
research community when in 1998 he was able to determine the spatial structure
of a potassium channel. The selection committee said, because of his
contribution we can now “see” ions flowing through channels that can be opened and closed by different
Peter Agre , born in 1949 in Northfield , Minnesota, USA. In 1974, he got the
Medical Doctor at Johns Hopkins University School of Medicine, Baltimore, USA.
He is the professor of Biological Chemistry and Professor of Medicine at Johns
Hopkins University School of Medicine, Baltimore, USA.
Roderick MacKinnon, born in 1956, grew up in Burlington outside Boston, USA. In
1982, He got Medical Doctor at Tufts Medical School, Boston, USA. He is the
professor of Molecular Neurobiology and Biophysics at The Rockefeller
University in New York, USA.
Uncover the Secrets of Human Channel
How Does The Channel Form? In all cells and a serials of biochemical process, there exists widely the
propagation of the electronics and ion -- Biology current phenomena. In the
process of metabolism, all organs generate the biology electricity, such as,
heart electricity, brain electricity and muscle electricity with different
voltage, i.e. the heart voltage – 90mV, brain voltage- 60mV. Because the body is a conductor, the directional
flow of bioelectricity likes a river from the beginning to the end and the
channel system cover the whole body. There are 12 channels in whole body which
connect every part of the body, heart, liver, bone and skin etc. through
divergent collateral, tertiary collaterals, superficial collaterals and make
them an union. Therefore, the channel system is an energy circulation system,
different from other system. It is the first substance- electrical circulation
The Existing Of The Channel- The channel is the channel for the bioelectricity movement. When the channel
circulates, the horniness layer becomes thinner, the substance base with
low-resistance. Meanwhile, the dermis, hypodermis connective tissue nerve will
be centralized relatively. Many tests in the hypodermis electricity-conduction
illustrate most of hypodermis low-resistance points can be connected into the
symmetry and stable low-resistance channel line same as the direction of the
classical channel. Autopsy also find the low-resistance circuitry in the body.
Because the channel line is the bioelectricity channel, autopsy doesn’t find the independent channel tissue. Nowadays, some scholars support this
point of view.
The Principle For Forming The Channel- As we know, the electricity must have the return way, or the electricity can’t go through successfully. In the activities, all cells generate the
bioelectricity. The current cover the whole body and takes part in the
transportation function of cell membranes, nerve propagation, muscle shrink and
blood circulation etc. Now, we know some systems with bioelectricity including
nerve, movement and blood circulation, digestion system etc. These systems have
the activities of the bioelectricity and produce the voltage; we take it as the
live line. Then from the point of electrology, we propose a serious problem-
where is the null line? The answer is the null line is the channel.
Therefore, the channel system is the first circulation system. It’s the only system across the other systems.
The Nature Of The Channel System
• Only effective when unblocking. The channel system maintains the balance of the
bioelectricity distribution. Whichever part of the body is attacked by the
diseases can cause the partial unbalance and cut off or block the current, so
the channel is only effective when unblocking. Keeping the low-resistance of
the channel is the necessary condition to keep the channel system work
• Output the positive electricity to outside and input the negative electricity
In the resting cell, the electricity potential is negative(-) inside, and
positive outside, the resting potential is about -90mV. The human body is the
natural biobattery made up of the electriferous cells. Every cell equals
capacitor with positive and negative electricity (negative inside and negative
outside). Some scholars think there are more positive electricity in the active
and ill status. The process outputting the positive and making up the negative
will be finished under the help of the channel system. This function explain
touching “earth gas” and explain the negative ion is useful to the health.
The Channel And The Pathology- Under the status of diseases, the bio-current is disordered and the related
resistance value changes. The change of the resistance value and electricity
potential influences the activities of the partial cells, then influence their
metabolism, the stronger power, the deeper influence, vice versa. The sequence
is nerve system, movement system, incretion system, circulation system and
In the channel system, partial bioelectricity is cut off or blocked without the
organic pathological change which is called sub-health status.
The Channel And Diagnose- Under the status of diseases, the bioelectricity disorder influences the partial
cell metabolism. Some pathological part will become loose, depressed, knur and
straps etc positive reflection. Sometimes, the skin color in the related
acupoint will change. All these changes provide the information to the
observation diagnose of Chinese Medicine. The experienced doctor can diagnose
through observe partial shape and color change. That’s the theory of observing, tongue and ear diagnose.
The Channel Characters- Every organ, cell has its own bioelectricity and form human body magnetic field
which keep radiating. That’s the called “Body Lights”. Actually, it’s just a circulated radiation field around human body.
Anthropotomy doesn’t find the independent channel tissue, but the channel tissue must be different
from the surrounding tissue. Because the main function of the channel tissue is
the gateway of electricity and it only needs the low-resistance, it’s unnecessary to have the anthroponomy shape.
The channel tissue is very fragile. For the critical patient, the direction of
the channel is disordered and is easy to rebuild the channel transportation
under the high negative voltage. This illustrates the channel tissue is easily
formed on the non-channel tissue, at the same time, the normal channel tissue
disappears and weakens easily. The substance structure of the channel tissue is
very simple and not so easy to be distinguished from the other tissues. Hence,
the correct exploration of the channel can’t use intervention, or high voltage, high current, high magnetic field and
isotopes etc which is too strong to the channel. Or the exploration won’t be correct. That’s to say, hunting for a gentle, non-intervention test is very important to prove
The channel tissue has different chemical structure, because its content of
metal ion is very high. The current of the channel tissue forms when the
accumulation of the electron charge in some degree change the chemical
structure of the channel and the electron charge enter the changed channel
tissue. Then the resistance of the channel will become lower to change the
chemical structure of next channel tissue. Finally, the fluctuating and slow
electrical movement comes into being.
The voltage fluctuation of the heart electricity is the inducement factor to for
the channel current. The speed of the channel is 2-6cm/m. It will become slow
or stop in the status of diseases and sub-health. It will become fast with the
increase of heart rate in the exciting status. Hence, the channel must exist in
the dynamic and chemistry-changeable anatomic structure and it must be 3D. This
kind of structure is the invisible anatomic status.
The channel pulse is superposed with the microscopic tissue of other tissues. In
the blood tissue, it is superposed with arteriole and venule. In the nerve
tissue, it is superposed with nerve bundle and ganglion etc. It is one tissue
which can adjust the other tissue. Thereby, it’s very important whether this tissue works very well.
The Channel Nature And The Ion Cleanse- The ion cleanse can keep the channel flowing. During the process of
detoxification, the cuff connect three Yang and Yin channel of hands with three
Yang and Yi channel of feet. Detoxification helps to activate and dredge the
channel. The channel theory is the important part in basic theory of Chinese
Medicine, because the body generates complex bioelectricity, such as heart
electricity, muscle electricity and brain electricity etc. when metabolism. All
these form the channel tissue in the whole body. This tissue takes part in the
activities of all other tissues, so the channel should be the circulation
system in the body bioelectricity.
The Principle Of The Ion Cleanse- The human body is constituted by the cells. And the cell is made up of cell
membranes, cytoplasm and nucleolus. The cell membrane is the important channel
for the substance exchange inside and outside the cell. It keeps the stability
of inside and outside environment. When the membranes electricity potential is
from －70～－90MV, the cell can work well in the exchange and remove the toxin. With the decay
of the body function, there is a lot of toxin accumulated. The cell damage,
membranes electricity potential change, the permeability of membranes declining
and the detoxification ability declining, all these make the toxin can’t be removed well from the cell. The toxin accumulation lowers the immune and
makes premature senility and sub-health etc.
The ion cleanse can generate the negative electricity potential field. Thanks to
the conductive ability of the human body, the body can have the same
equipotential field as the ion water after the feet are put in the ion water
with negative ion. It can enhance the transportation function of the
sodium-potassium pump, keep the right membrane electricity potential, recover
the energy, enhance the detoxification. Under the role of the negative
electricity potential field, the toxin in the cells is removed into the water
through 20 thousands of pores and the water color will change because the toxin
reacts with all kinds of ions in the water – “visible detoxification”. Its effect can be tested and compared by blood test, urine test etc other
regular tests before and after the feet bathing—“The effect can be tested.”
The Ion Cleanse Characters- The ion cleanse is developed on the basis of physics, physiology,
electrochemistry, dialysis, iontophoresis and toxicology. It can activate the
cells, improve the activity of the cells, repair the cells by using feet
channel therapy, the cell therapy and targeted natural detoxification therapy.
The whole detoxification is safe, cosy, fast, effective and it can be seen,
tested and smelled.
The Work Theory Of The Ion-Cleanse- The Ion-Cleanse process is an amazing cleansing method for detoxifying your
entire body by bathing your feet in warm water while using positive and
negative ions from an ion generator. The process is also known as electrolysis.
The array element is the actual ion generator device that sits down into the
water and creates the ion charge and flow within that solution. It attaches to
the power supply, which controls the array element ion flow and change.
The Advantages Of The Ion Cleanse- The health and life of the people lie on the volume of electricity in body. If a
healthy person, he or she should be taken with 80% negative electricity
(usually said negative ions) and 20% positive electricity (usually said
positive ions). But the human body is like a giant magnet that attracts and
holds onto toxins. Heavy metals, partially oxidized fats, disassimilated
proteins, cholesterol deposits, uric acid, plaque, lactic acid and the vast
array of chemicals that pervade our water, air and food attach themselves
ionized form to joints, organs arteries, nerves and tissues. These toxins
disrupt normal body functions creating an environment for disease, allergies,
and immune system problems.
Ion generating technology has been around for several decades. It is this
technology that is the secret to success in the Ion-Cleanse process by using an
alternating positive and negative ion charge during the same treatment. This
important discovery now makes it possible to remove unwanted toxic material
from everyone regardless of the electrical charges the toxin may hold.
Ions are charged atoms that have gained or lost an electron, which causes them
to set up a magnetic field capable of attracting and neutralizing oppositely
charged particles and pulling them out of the body through a process called
Osmosis is a scientific term used to describe the movement of particles through
a cellular membrane from a higher concentration to a lower concentration. The
lower concentration in this case refers to the
ion field set up by the system in the water. Often times it is possible to
reduce pain, swelling, edema and other symptoms caused by a long-term life
style and a chronic toxic buildup in the body. The long term effectiveness of
the detoxification process depends on the other life-enhancing and life style
changes that the patient is willing to make.
Purgative Detoxification, Easy And Healthy- It is an external detoxification method, which removes toxins through your feet.
The body detoxifies while you are comfortably seated with your feet placed in a
container of warm water. This is a very efficient way to remove toxic
accumulations regardless of where they are located in the body. The Ion-Cleanse
Process generates a stream of positive and negative ions (charged atoms), which
attract and attach themselves to oppositely charged toxic particles and draws
them out of the body through the skin. Each session takes about 30 minutes. The
array goes into the water with the hands, feet, or body, and the power supply
delivers a small amount of direct current into the array, which causes the
metals within it, in combination with water, and salt, to generate positively
and negatively charged ions.